Cct2 chaperonin

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August undefined, 2024

WebMar 5, 2024 · Go to complete Gene record for CCT2; Go to Variation Viewer for CCT2 variants; Summary. The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing … WebJun 14, 2024 · This selective CCT2-solid aggregates association may be influenced by the protein conformation in solid aggregates: (1) Solid aggregates contain misfolded …

Chaperoning solid aggregates for autophagy - Nature

WebApr 30, 2024 · CT20p thus demonstrates that CCT2 and the chaperonin complex can be therapeutically targeted and have biological outcomes such decreasing tumor growth. Herein we show the value of CCT2 as a druggable target by demonstrating its role as a cell cycle regulator that intersects with key proliferative factors like MYC and CCND1. WebJul 15, 2024 · Circoviruses are the smallest single-stranded DNA viruses that infect mammalian species, avian species, fish, and insects. The infections of circoviruses are known to be associated with a series of fatal diseases, but the protease of circovirus still remains unknown. In this research, we identified viral capsid protein (Cap) as the … packstation 192 roxheim

TRiC/CCT Chaperonin: Structure and Function - ResearchGate

WebApr 14, 2024 · CCT2 associates with aggregation-prone proteins independent of cargo ubiquitination and interacts with autophagosome marker ATG8s through a non-classical … WebSep 15, 2024 · Such data suggest that CCT2 may have a unique and essential activity in the chaperonin complex. CCT2 is postulated to be the first subunit to load onto a CCT5 homo-oligomer “template” that initiates assembly of the CCT complex , has a long half-life (~8 hrs) , and has one of the highest affinities for ATP . WebApr 22, 2014 · The primary cytosolic eukaryotic chaperonin is the tailless complex protein-1 (TCP-1) ring complex (commonly abbreviated TRiC, and also known as complex containing TCP-1 or CCT). TRiC is a large complex (1 MDa) composed of eight homologous but distinct subunits (CCT 1–8), arranged in two stacked octameric rings to form two interior … lsuhsc moodle new orleans

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CCT2 chaperonin containing TCP1 subunit 2 - NIH Genetic …

WebApr 30, 2024 · CCT, a type II chaperonin, is a multi-subunit protein-folding complex that interacts with many oncoproteins and mutant tumor suppressors. CCT subunits are … WebDescription: Homo sapiens chaperonin containing TCP1, subunit 4 (delta) (CCT4), transcript variant 1, mRNA. RefSeq Summary (NM_006430): The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT … packstation 193 berlinWebApr 5, 2024 · Altogether, CCT2 has a double role in proteostasis: as a component of a chaperone complex it prevents protein aggregation, and as a monomer it functions as … packstation 196 40723 hilden

"WebThe Township of Fawn Creek is located in Montgomery County, Kansas, United States. The place is catalogued as Civil by the U.S. Board on Geographic Names and its elevation … " - Cct2 chaperonin

Cct2 chaperonin

WebApr 14, 2024 · The current work identifies the chaperonin subunit CCT2 as an aggrephagy receptor which facilitates the clearance of aggregation-prone proteins. Therefore, the …

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WebJun 28, 2024 · Several studies have revealed the presence of two functional hemispheres in the CCT oligomer 13,40,41,42, one formed by the adjacent CCT5, CCT2, CCT4, and CCT1 subunits on one side (the CCT2 ... Web伪狂犬病毒gE2.0抗体ELISA试剂盒公司正在销售的产品：酮戊二suan受体1ELISA检测试剂盒 OXGR1Huma...

Webchaperonin has a build-in lid in the apical domain that can shut close the chamber (Fig. 19.2a–c). The archaea group II chaperonin has eight or nine subunits per ring, WebHere, we identify the chaperonin subunit CCT2 as an autophagy receptor regulating the clearance of aggregation-prone proteins in the cell and the mouse brain. CCT2 associates with aggregation-prone proteins independent of cargo ubiquitination and interacts with autophagosome marker ATG8s through a non-classical VLIR motif.

WebOur recent work identifies the chaperonin subunit CCT2 as a new type of aggrephagy receptor specifically facilitating the autophagic clearance of solid protein aggregates, and indicates that multiple aggrephagy pathways act in parallel to remove different types of protein aggregates. In addition, this work reveals a functional switch of the ... WebAug 28, 2024 · Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes. Exp Cell Res. 2015;332:223–35.

WebMar 29, 2024 · CCT2 chaperonin containing TCP1 subunit 2 [ (human)] Gene ID: 10576, updated on 8-Jan-2024. Summary. The protein encoded by this gene is a molecular …

WebCCT2 (chaperonin containing TCP1 subunit 2) as the first identified specific aggrephagy receptor in mammals. The switch of CCT2ʹs role from a chaperonin to a specific aggrephagy receptor is achieved by CCT2 monomer formation. CCT2 functions independently of ubiquitin and the TRiC complex to packstation 196 poingWebChaperonin containing tailless complex polypeptide 1 (CCT) or tailless complex polypeptide 1 ring complex (TRiC) is an essential eukaryotic molecular chaperone. It is a multi-subunit oligomer of two rings of eight individual protein subunits. When assembled, each of the eight CCT subunits occupies a specific position within each chaperonin ring. Thus a … packstation 196WebSep 26, 2024 · Therefore, the CCT chaperonin is a novel regulator of Orai1 trafficking and, as such, a modulator of Ca 2+ signaling and effector activation kinetics. INTRODUCTION. Ca 2+ is a ubiquitous intracellular messenger that is central to many cell physiological processes ranging from cellular proliferation to cell death (1, 2). ... CCT1, CCT2, and … packstation 193 würzburgWebJan 21, 2024 · Chaperonin-containing TCP-1 (CCT or TRiC) is a multi-subunit complex that folds many of the proteins essential for cancer development. CCT is expressed in diverse cancers and could be an ideal ... packstation 197 wilhelmshavenWebAug 21, 2024 · Chaperonin‐containing TCP‐1 subunit 2 (CCT2)’s dual function in preventing protein aggregation and removing protein aggregates. CCT2 can function as a component of the TRiC complex to suppress protein misfolding and aggregation; also, it can act as a monomeric autophagy receptor to facilitate the clearance of solid protein … packstation 195 bonnWebFeb 5, 2024 · Orthologous to human CCT2 (chaperonin containing TCP1 subunit 2). [provided by Alliance of Genome Resources, Apr 2024] Other designations. T-complex protein 1 subunit beta, CCT-beta, TCP-1-beta, chaperonin subunit 2 (beta) GeneRIFs: Gene References Into Functions. CCT2 is an aggrephagy receptor for clearance of solid … lsuhsc new orleans school of medicineWebNational Center for Biotechnology Information packstation 196 offenbach