Webb1 juni 2015 · In the present study, the diagnostic value of DLST on anti-TB drug-induced ADRs was investigated in 272 TB patients treated with the first-line anti-TB drugs, INH, RFP, EMB, and PZA. The sensitivity of DLST in the diagnosis of ADRs associated with the 4 drugs varied from 23.1% to 57.8%, and the specificity varied from 93.4% to 98.8%. WebbSM INH RFP EMB Clinical drug-resistant M. tuberculosis strain (K0903557, resistant to INH) 30 30 0.2 2.5 0.25 <1.6 Clinical drug-sensitive M. tuberculosis strain (0907762) 10 ND b <0.1 0.025 10 <1.6 M. avium reference strain (ATCC 25291) >60 >60 20 5 30 3 M. intracellulare reference strain
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WebbFrom 2013 to 2024, the resistance rates of rifampicin (RFP) and isoniazid (INH) decreased significantly, whereas the resistance rates of ethambutol (EMB) and streptomycin (SM) increased in patients with suspected DR-TB. Webb18 apr. 2016 · Susceptibility testing for INH, RFP, EMB, and SM was performed on L-J medium at the following concentrations 14 0.2, 40, 2.0, and 4.0 μg/mL, respectively. The isolates were considered to be resistant if there was more than 1% growth on medium containing anti-TB drugs as compared with the growth on drug-free medium. shipped new debit card fraud
Analysis of influencing factors on the plasma concentration of first ...
Webb29 apr. 2024 · Isoniazid (INH), rifampicin (RFP), ethambutol (EMB), and pyrazinamide (PZA) are the most commonly used first-line anti-TB drugs in clinical practice . The efficacy of anti-TB drugs is influenced by several factors, including the metabolic status of the tubercle bacilli in the lesion( 3 ), drug resistance, comorbidities ( 4 ), drug dose, and … Webb16 feb. 2024 · Drug resistance was defined as resistance to any of the following drugs: isoniazid (INH), rifampin (RFP), streptomycin (STR), levofloxacin (LVX), and ethambutol (EMB) using 1, 1, 2, 1, and 5 μg/mL, respectively, as the critical concentration. WebbAbbreviations: INH, isoniazid; RFP, rifampicin; EMB, ethambutol; SM, streptomycin. Drug Resistance Trends in RR-TB and MDR-TB Among New and Previously Treated Cases with Suspected DR-TB, 2013 to 2024 Among new cases with suspected DR-TB, the rate of RR-TB decreased from 15.09% in 2013 to 3.00% in 2024 with an average annual decrease … queen carpets by shaw