WebSimvastatin-diltiazem drug interaction resulting in rhabdomyolysis and hepatitis Tenn Med. 2001 Sep;94(9):339-41. Authors N Kanathur 1 , M G Mathai, R P Byrd Jr, C L Fields, T M Roy. Affiliation 1 Veterans Affairs Medical Center 111-B, PO Box 4000, Mountain Home, TN 37684-4000, USA. PMID: 11550401 Abstract ... WebA total of 161 drugs are known to interact with pravastatin . Pravastatin is in the drug class statins . Pravastatin is used to treat the following conditions: High Cholesterol. High Cholesterol, Familial Heterozygous. Hyperlipoproteinemia. Hyperlipoproteinemia Type IIa, …
Oral Anticoagulant Drug Interactions with Statins: Case Report of ...
WebJan 16, 2012 · The literature supports a drug interaction between warfarin and fluvastatin due to the strong affinity of fluvastatin for the cytochrome P450 enzyme 2D6. ... Pravastatin does not appear to interact with warfarin but has caused an increased INR when combined with the anticoagulant fluindione. Thus, ... WebThere was no change in the time to peak concentration for simvastatin and simvastatin acid. Conclusion: Diltiazem coadministration resulted in a significant interaction with simvastatin, probably by inhibiting CYP3A-mediated metabolism. Concomitant use of diltiazem or other potent inhibitors of CYP3A with simvastatin should be avoided, or close ... check content security policy
Calcium supplements: Do they interfere with blood pressure drugs?
WebMar 31, 2014 · Diltiazem has been found responsible for rhabdomyolysis secondary to interaction with simvastatin and atorvastatin (Kanathur et al. 2001, Lewin et al. 2002; Gladding and Pilmore 2004; Hu et al. 2011). The most recent recommendation of FDA has reconsidered the label for simvastatin dose when combined with non-DHP CCB from 20 to … WebThe interaction of diltiazem with lovastatin and pravastatin. ... (20 mg/d) in combination with diltiazem. Interactions have been reported for fluvastatin in combination with the CYP2C9 substrate warfarin, 63 and an increased serum concentration of fluvastatin has been reported when it is coadministered with diclofenac or fluconazole. 53,64 ... WebA pharmacokinetic interaction between diltiazem and cyclosporine has been observed during studies involving renal and cardiac transplant patients. In renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of … flashdance maniac remake