WebMar 11, 2013 · As rrp1 is also highly expressed in the feeding tick , it may assist the induction of bosR following a blood meal. Thus, a decrease in bosR expression in the rrp1 … WebJan 6, 2016 · The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes. Mol Microbiol 81, 219–231. Article PubMed Central CAS PubMed Google Scholar Miller, C.L., Karna, S.L.R., and Seshu, J. (2013). ... Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic …
(PDF) The Hybrid Histidine Kinase Hk1 Is Part of a Two
WebOct 1, 2015 · The Hk1/Rrp1 two-component system (TCS) in Borrelia burgdorferi consists of a hybrid histidine kinase and a response regulator with diguanylate cyclase activity, respectively. Phosphorylated Rrp1 catalyzes the synthesis of c-di-GMP, a second messenger associated with bacterial life-style control networks. WebJan 23, 2009 · Rrp1 is the only Borrelia protein that carries a GGDEF domain, which is associated with c-di-GMP production. C-di-GMP is an important secondary messenger molecule that influences the expression of proteins involved in a wide range of core biological functions (Cotter and Stibitz, 2007). toys shop dog pet littlest
Cyclic Di-GMP receptor PlzA controls virulence gene expression …
WebApr 16, 2024 · In the tick-borne pathogens, Borreliella burgdorferi and Borrelia hermsii, c-di-GMP is produced by a single diguanylate cyclase (Rrp1). In these pathogens, the Plz … WebThe two-component response regulator Rrp2 is a key activator controlling the production of numerous virulence factors of Borrelia burgdorferi, the Lyme disease pathogen. Previously it was shown that the cognate histidine kinase HK2 is not required for Rrp2 activation in vitro, nor for mammalian infection upon needle inoculation, raising the question whether HK2 … WebA mutant strain of rrp1 has been found to cause growth deficits with Borrelia burgdorferi. [6] In Escherichia coli, the chb operon is involved with the utilization of cellobiose and β-glucosides chitobiose. The chbG gene of the chb Operon encodes a chitooligosaccharide deacetylase. [7] toys shop coventry